diff --git a/src/core/hle/kernel/memory.cpp b/src/core/hle/kernel/memory.cpp
index 95d3a6bf6a..d990d05697 100644
--- a/src/core/hle/kernel/memory.cpp
+++ b/src/core/hle/kernel/memory.cpp
@@ -69,8 +69,8 @@ void MemoryInit(u32 mem_type) {
     // app_mem_malloc does not always match the configured size for memory_region[0]: in case the
     // n3DS type override is in effect it reports the size the game expects, not the real one.
     config_mem.app_mem_alloc = memory_region_sizes[mem_type][0];
-    config_mem.sys_mem_alloc = memory_regions[1].size;
-    config_mem.base_mem_alloc = memory_regions[2].size;
+    config_mem.sys_mem_alloc = static_cast<u32_le>(memory_regions[1].size);
+    config_mem.base_mem_alloc = static_cast<u32_le>(memory_regions[2].size);
 }
 
 void MemoryShutdown() {
diff --git a/src/core/memory.cpp b/src/core/memory.cpp
index 9a5661a990..93ffe99387 100644
--- a/src/core/memory.cpp
+++ b/src/core/memory.cpp
@@ -37,7 +37,7 @@ PageTable* GetCurrentPageTable() {
     return current_page_table;
 }
 
-static void MapPages(PageTable& page_table, VAddr base, u32 size, u8* memory, PageType type) {
+static void MapPages(PageTable& page_table, VAddr base, u64 size, u8* memory, PageType type) {
     LOG_DEBUG(HW_Memory, "Mapping %p onto %08X-%08X", memory, base * PAGE_SIZE,
               (base + size) * PAGE_SIZE);
 
@@ -58,13 +58,13 @@ static void MapPages(PageTable& page_table, VAddr base, u32 size, u8* memory, Pa
     }
 }
 
-void MapMemoryRegion(PageTable& page_table, VAddr base, u32 size, u8* target) {
+void MapMemoryRegion(PageTable& page_table, VAddr base, u64 size, u8* target) {
     ASSERT_MSG((size & PAGE_MASK) == 0, "non-page aligned size: %08X", size);
     ASSERT_MSG((base & PAGE_MASK) == 0, "non-page aligned base: %08X", base);
     MapPages(page_table, base / PAGE_SIZE, size / PAGE_SIZE, target, PageType::Memory);
 }
 
-void MapIoRegion(PageTable& page_table, VAddr base, u32 size, MMIORegionPointer mmio_handler) {
+void MapIoRegion(PageTable& page_table, VAddr base, u64 size, MMIORegionPointer mmio_handler) {
     ASSERT_MSG((size & PAGE_MASK) == 0, "non-page aligned size: %08X", size);
     ASSERT_MSG((base & PAGE_MASK) == 0, "non-page aligned base: %08X", base);
     MapPages(page_table, base / PAGE_SIZE, size / PAGE_SIZE, nullptr, PageType::Special);
@@ -72,7 +72,7 @@ void MapIoRegion(PageTable& page_table, VAddr base, u32 size, MMIORegionPointer
     page_table.special_regions.emplace_back(SpecialRegion{base, size, mmio_handler});
 }
 
-void UnmapRegion(PageTable& page_table, VAddr base, u32 size) {
+void UnmapRegion(PageTable& page_table, VAddr base, u64 size) {
     ASSERT_MSG((size & PAGE_MASK) == 0, "non-page aligned size: %08X", size);
     ASSERT_MSG((base & PAGE_MASK) == 0, "non-page aligned base: %08X", base);
     MapPages(page_table, base / PAGE_SIZE, size / PAGE_SIZE, nullptr, PageType::Unmapped);
@@ -334,7 +334,7 @@ u8* GetPhysicalPointer(PAddr address) {
     return target_pointer;
 }
 
-void RasterizerMarkRegionCached(PAddr start, u32 size, int count_delta) {
+void RasterizerMarkRegionCached(PAddr start, u64 size, int count_delta) {
     if (start == 0) {
         return;
     }
@@ -413,13 +413,13 @@ void RasterizerMarkRegionCached(PAddr start, u32 size, int count_delta) {
     }
 }
 
-void RasterizerFlushRegion(PAddr start, u32 size) {
+void RasterizerFlushRegion(PAddr start, u64 size) {
     if (VideoCore::g_renderer != nullptr) {
         VideoCore::g_renderer->Rasterizer()->FlushRegion(start, size);
     }
 }
 
-void RasterizerFlushAndInvalidateRegion(PAddr start, u32 size) {
+void RasterizerFlushAndInvalidateRegion(PAddr start, u64 size) {
     // Since pages are unmapped on shutdown after video core is shutdown, the renderer may be
     // null here
     if (VideoCore::g_renderer != nullptr) {
@@ -427,7 +427,7 @@ void RasterizerFlushAndInvalidateRegion(PAddr start, u32 size) {
     }
 }
 
-void RasterizerFlushVirtualRegion(VAddr start, u32 size, FlushMode mode) {
+void RasterizerFlushVirtualRegion(VAddr start, u64 size, FlushMode mode) {
     // Since pages are unmapped on shutdown after video core is shutdown, the renderer may be
     // null here
     if (VideoCore::g_renderer != nullptr) {
diff --git a/src/core/memory.h b/src/core/memory.h
index 71ba487fc6..91bd4d8891 100644
--- a/src/core/memory.h
+++ b/src/core/memory.h
@@ -45,7 +45,7 @@ enum class PageType {
 
 struct SpecialRegion {
     VAddr base;
-    u32 size;
+    u64 size;
     MMIORegionPointer handler;
 };
 
@@ -247,17 +247,17 @@ u8* GetPhysicalPointer(PAddr address);
  * Adds the supplied value to the rasterizer resource cache counter of each
  * page touching the region.
  */
-void RasterizerMarkRegionCached(PAddr start, u32 size, int count_delta);
+void RasterizerMarkRegionCached(PAddr start, u64 size, int count_delta);
 
 /**
  * Flushes any externally cached rasterizer resources touching the given region.
  */
-void RasterizerFlushRegion(PAddr start, u32 size);
+void RasterizerFlushRegion(PAddr start, u64 size);
 
 /**
  * Flushes and invalidates any externally cached rasterizer resources touching the given region.
  */
-void RasterizerFlushAndInvalidateRegion(PAddr start, u32 size);
+void RasterizerFlushAndInvalidateRegion(PAddr start, u64 size);
 
 enum class FlushMode {
     /// Write back modified surfaces to RAM
@@ -270,6 +270,6 @@ enum class FlushMode {
  * Flushes and invalidates any externally cached rasterizer resources touching the given virtual
  * address region.
  */
-void RasterizerFlushVirtualRegion(VAddr start, u32 size, FlushMode mode);
+void RasterizerFlushVirtualRegion(VAddr start, u64 size, FlushMode mode);
 
 } // namespace Memory
diff --git a/src/core/memory_setup.h b/src/core/memory_setup.h
index c58baa50b6..ff4dcc936b 100644
--- a/src/core/memory_setup.h
+++ b/src/core/memory_setup.h
@@ -17,7 +17,7 @@ namespace Memory {
  * @param size The amount of bytes to map. Must be page-aligned.
  * @param target Buffer with the memory backing the mapping. Must be of length at least `size`.
  */
-void MapMemoryRegion(PageTable& page_table, VAddr base, u32 size, u8* target);
+void MapMemoryRegion(PageTable& page_table, VAddr base, u64 size, u8* target);
 
 /**
  * Maps a region of the emulated process address space as a IO region.
@@ -26,7 +26,7 @@ void MapMemoryRegion(PageTable& page_table, VAddr base, u32 size, u8* target);
  * @param size The amount of bytes to map. Must be page-aligned.
  * @param mmio_handler The handler that backs the mapping.
  */
-void MapIoRegion(PageTable& page_table, VAddr base, u32 size, MMIORegionPointer mmio_handler);
+void MapIoRegion(PageTable& page_table, VAddr base, u64 size, MMIORegionPointer mmio_handler);
 
-void UnmapRegion(PageTable& page_table, VAddr base, u32 size);
+void UnmapRegion(PageTable& page_table, VAddr base, u64 size);
 }
diff --git a/src/video_core/rasterizer_interface.h b/src/video_core/rasterizer_interface.h
index 8ef7e74c77..4b099bc555 100644
--- a/src/video_core/rasterizer_interface.h
+++ b/src/video_core/rasterizer_interface.h
@@ -36,11 +36,11 @@ public:
     virtual void FlushAll() = 0;
 
     /// Notify rasterizer that any caches of the specified region should be flushed to 3DS memory
-    virtual void FlushRegion(PAddr addr, u32 size) = 0;
+    virtual void FlushRegion(PAddr addr, u64 size) = 0;
 
     /// Notify rasterizer that any caches of the specified region should be flushed to 3DS memory
     /// and invalidated
-    virtual void FlushAndInvalidateRegion(PAddr addr, u32 size) = 0;
+    virtual void FlushAndInvalidateRegion(PAddr addr, u64 size) = 0;
 
     /// Attempt to use a faster method to perform a display transfer with is_texture_copy = 0
     virtual bool AccelerateDisplayTransfer(const GPU::Regs::DisplayTransferConfig& config) {
diff --git a/src/video_core/renderer_opengl/gl_rasterizer.cpp b/src/video_core/renderer_opengl/gl_rasterizer.cpp
index 7e09e4712a..becaf7bde3 100644
--- a/src/video_core/renderer_opengl/gl_rasterizer.cpp
+++ b/src/video_core/renderer_opengl/gl_rasterizer.cpp
@@ -889,12 +889,12 @@ void RasterizerOpenGL::FlushAll() {
     res_cache.FlushAll();
 }
 
-void RasterizerOpenGL::FlushRegion(PAddr addr, u32 size) {
+void RasterizerOpenGL::FlushRegion(PAddr addr, u64 size) {
     MICROPROFILE_SCOPE(OpenGL_CacheManagement);
     res_cache.FlushRegion(addr, size, nullptr, false);
 }
 
-void RasterizerOpenGL::FlushAndInvalidateRegion(PAddr addr, u32 size) {
+void RasterizerOpenGL::FlushAndInvalidateRegion(PAddr addr, u64 size) {
     MICROPROFILE_SCOPE(OpenGL_CacheManagement);
     res_cache.FlushRegion(addr, size, nullptr, true);
 }
diff --git a/src/video_core/renderer_opengl/gl_rasterizer.h b/src/video_core/renderer_opengl/gl_rasterizer.h
index 46c62961c3..d02c157e85 100644
--- a/src/video_core/renderer_opengl/gl_rasterizer.h
+++ b/src/video_core/renderer_opengl/gl_rasterizer.h
@@ -42,8 +42,8 @@ public:
     void DrawTriangles() override;
     void NotifyPicaRegisterChanged(u32 id) override;
     void FlushAll() override;
-    void FlushRegion(PAddr addr, u32 size) override;
-    void FlushAndInvalidateRegion(PAddr addr, u32 size) override;
+    void FlushRegion(PAddr addr, u64 size) override;
+    void FlushAndInvalidateRegion(PAddr addr, u64 size) override;
     bool AccelerateDisplayTransfer(const GPU::Regs::DisplayTransferConfig& config) override;
     bool AccelerateTextureCopy(const GPU::Regs::DisplayTransferConfig& config) override;
     bool AccelerateFill(const GPU::Regs::MemoryFillConfig& config) override;
diff --git a/src/video_core/swrasterizer/swrasterizer.h b/src/video_core/swrasterizer/swrasterizer.h
index 6d42d74090..04ebd53120 100644
--- a/src/video_core/swrasterizer/swrasterizer.h
+++ b/src/video_core/swrasterizer/swrasterizer.h
@@ -21,7 +21,7 @@ class SWRasterizer : public RasterizerInterface {
     void DrawTriangles() override {}
     void NotifyPicaRegisterChanged(u32 id) override {}
     void FlushAll() override {}
-    void FlushRegion(PAddr addr, u32 size) override {}
-    void FlushAndInvalidateRegion(PAddr addr, u32 size) override {}
+    void FlushRegion(PAddr addr, u64 size) override {}
+    void FlushAndInvalidateRegion(PAddr addr, u64 size) override {}
 };
 }